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Adverse effects of Paracetamol are rare but hypersensitivity including skin rash may occur. The hazards of overdose are greater in those with non-cirrhotic alcoholic liver disease. Information is updated daily. startxref By continuing to browse the site you are agreeing to our policy on the use of cookies. Plasma-protein binding is negligible at usual therapeutic concentrations but increases with increasing concentrations. >> Paracetamol is excreted in breast milk but not in a clinically significant amount. Start typing to retrieve search suggestions. 0000002013 00000 n Serv. Safety Data Sheets (SDSs) containing safety information for the complete catalog of USP Reference Standards are available from this online searchable index. /Length 2110 It is metabolised in the liver. 0000010060 00000 n >>

If vomiting is not a problem, oral methionine may be a suitable alternative for remote areas, outside hospital. Get complimentary six-month access to USP-NF Online. A minor hydroxylated metabolite which is usually produced in very small amounts by mixed-function oxidases in the liver and which is usually detoxified by conjugation with liver glutathione may accumulate following paracetamol overdosage and cause tissue damage. �8V�#�nl��UB �a(!� �)oOE�E��} ~ZqG!�A�E�Q���ѧ:M�k��$O-ώ�m���nP�6\��������%�!��Ja��_Vzo�� <<

169 24 Liver damage may become apparent 12 to 48 hours after ingestion. • Domperidone – may increase speed of absorption of paracetamol. <]>> `.

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Adverse effects of Paracetamol are rare but hypersensitivity including skin rash may occur.

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Cardiac arrhythmias and pancreatitis have been reported. Reporting suspected adverse reactions after authorisation of the medicinal product is important. Alternative presentations of paracetamol are recommended for paediatric usage in order to obtain suitable doses of less than 500mg. Liver damage is possible in adults who have taken 10g or more of Paracetamol.

• Colestyramine – may reduce absorption if given within one hour of paracetamol. Product may also be supplied in bulk hospital packs for reassembly, in polybags contained in tins, skillets or polybuckets filled with suitable cushioning material. Headache induced by overuse of analgesics (MOH medication-overuse headache) should not be treated by dose increase. /ViewerPreferences << It is excreted in the urine, mainly as the glucuronide and sulfate conjugates. • Imatinib - restriction or avoidance of concomitant regular paracetamol use should be taken with imatinib.

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Immediate medical advice should be sought in the event of an overdose, even if you feel well.

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Compliant with BS8404. Each tablet contains 500mg Paracetamol PhEur.

Very rare cases of serious skin reactions have been reported. Management of patients who present with serious hepatic dysfunction beyond 24h from ingestion should be discussed with the NPIS or a liver unit.

Paracetamol has analgesic and antipyretic actions similar to those of aspirin and hence is a suitable alternative for patients sensitive to aspirin. Available published data do not contraindicate breast feeding. Abnormalities of glucose metabolism and metabolic acidosis may occur. Since that time, new data have become available, and these have been incorporated into the monograph and taken into consideration in the present evaluation. To bookmark a medicine you must sign up and log in. When you use these standards together, you know you’re gaining value beyond the vial. 0000009709 00000 n 0 0000010204 00000 n Management should be in accordance with established treatment guidelines, see BNF overdose section. Pharmacotherapeutic group: Other analgesics and antipyretics, Anilides.

0000001680 00000 n 0000000795 00000 n 0000002280 00000 n Mallinckrodt also offers a line of direct compression Acetaminophen products, known as Compap™, that offer a unique particle size advantage to facilitate blending with other active pharmaceutical ingredients.