There were some experimental errors that have caused variation in my results compared to the theoretical solutions. A lab coat is required and must be worn once lab begins. Pay attention to these following. As we have to wash down the crystals before we carry out the suction filtration, some crystals might have dissolved.

Melting point is determined by using the optimelt melting apparatus. Aspirin is primarily used to treat pain as well as to avert cardiovascular disease. Experiment 10 will have you synthesize two esters of salicylic acid. This acid will then be used to make aspirin. The percent yield was about 76.7% whereas the temperature range is between 134.2 to 136.1 ÌŠÌŠC. The aspirin made in lab was more pure than the store bought aspirin rather than the salicylic acid when the ferric chloride test was performed. Required eye protection. Aspirin is an ester that has high molecular weight and it not soluble in water hence the solid can be separated by crystallization process. The temperature of an alcohol thermometer was equilibrated in a beaker of room temperature tap water.

The % yield of the aspirin was 132%. For preparation of Aspirin, acetic anhydride is added to the measured amount of salicylic acid. This part will have you synthesize aspirin from salicylic acid. %���� Methyl alcohol, ethyl alcohol, and isopropyl alcohol, for example, all have some properties in … The % yield of the aspirin was 132%. Here you will find material for Experiment 21 - Synthesis of Aspirin. �]]qYs�ʢ��P���z\�Z��pU/�ӳ�Lv��F$���1�N�t��v����� |s�o�Me��ߵ���Xt��iE�v�0+a�ա�j�c���s����mMn� ��$��5�����^�[K`1�r>�*gd%�������On*V?�h�۝{�gc���.��y�i? endobj The odor of the sample can then be noted by all lab members. Pay attention to the synthesis reactions in this experiment. Approx 30mL of hot distilled water is added to the solution. Copyright © 2003 - 2020 - UKEssays is a trading name of All Answers Ltd, a company registered in England and Wales. Since no other compounds will react with ferric chloride that means, the test is only positive for phenols. Major Chemical Concept. Number of moles = mass of substance ÷ molar mass of substance, Synthesis Reactions of Aspirin and Methyl Salicylate (click to enlarge). You will then add salicylic acid to one and your synthesized from Part A in another test tube.

Phenols react with ferric chloride to produce, a purple compound. The maximum allowable amount of Therefore we had to suction filtrate the whole mixture in the filter flask and hence, this might have led to presence of more impurities or lose in product. The maximum allowable amount of The temperature is set to 100 ÌŠC and then gradually heated up to determine the melting point. Aspirin is primarily used to treat pain as well as to avert cardiovascular disease.

endobj Then they are placed into the melting apparatus. Measure out ~3 g of salicylic acid on an analytical balance, recording its mass to the nearest 0.001 g. Transfer the salicylic acid into a second 125-mL Erlenmeyer flask (not the one with the water in it), and record the mass of the salicylic acid on your report sheet. Specifically, General Chemistry Laboratories A Freshman Workbook. Remember, the lab may change or be modified from semester to semester! %PDF-1.5 From this experiment, I have learnt how to carry out suction filtration in the right way and to be cautious at all time when handling chemicals and so on. A combination lock is required to lock your equipment drawer for the semester. A clean and dry watch glass is measured together with a filter paper and the weight is measured and recorded. Using the recorded amount of salicyclic acid used, you can find the expected amount of aspirin. endobj Fumehood is a local ventilation device that is designed to limit exposure to hazardous or noxious fumes, vapours and dust. The purpose of this lab is to synthesize and characterize high purity aspirin. Do not lose this container or its contents, you will use them later. discovered in 1897 by Felix Hoffman, it has since been used in over 50 over-the-counter medicines. We've received widespread press coverage since 2003, Your UKEssays purchase is secure and we're rated 4.4/5 on reviews.co.uk. The three main purpose of the fumehood are as follows: In the results, we calculate the percent yield and the melting temperature. Sulphuric acid is added and heated for a short period to complete reaction.

The main procedures are preparation of aspirin, recrystallisation of aspirin and lastly determining the melting point of the aspirin. This could be a number of reasons such as impurities or that the sample was not completely dry. <>>> Do you have a 2:1 degree or higher? The active ingredient of the drug Aspirin, acetylsalicylic acid can be synthesized through an esterification reaction between salicylic acid and acetic anhydride. Synthesis of Aspirin By: Jon Torre Purpose: To determine which of four catalysts yields the fastest reaction rate in the acetylation of salicylic acid (1) to form acetylsalicylic acid (2). *You can also browse our support articles here >, Protect the user carrying out the experiment. Aspirin is a drug that is usually used to relieve minor aches and pain and other medical uses such as anti-inflammatory medication.

Hence this might have affected the percent yield too. Must be worn at the start of the experiment and until leaving. stream Aspirin is an ester that has high molecular weight and it not soluble in water hence the solid can be separated by crystallization process. For this experiment, you will synthesize aspirin from salicylic acid.

This expected value will be compared to the amount obtain from your experiment to calculate percent yield. Use of them does not imply any affiliation with or endorsement by them. << /Length 4 0 R /Filter /FlateDecode >> ��_�����߳/�(�>�w����Q�}�����{����=��'9ޑ\%]��W�d ��U\E��{�� ?�).�a�� �q�L���+EY��@I�4��� N A fume hood is a large piece of equipment five enclosed sides of a work area, the bottom of which is most commonly located at a standing work height.

The objective of this experiment is to enable us to conduct the synthesis of aspirin, reinforce the skills of recrystallisation and reinforce the technique of melting point determination.