Vanillin showed much stronger antioxidant activity than did ascorbic acid and Trolox in the ORAC assay and OxHLIA.

Huangbai Liniment Accelerated Wound Healing by Activating Nrf2 Signaling in Diabetes. Phenolic acids such as vanillic acid are antioxidants that may also help prevent and repair DNA and cell damage that can lead to cancer and Parkinson's disease. Epub 2014 Nov 26. doi: 10.1093/jas/skaa259. Saravanakumar M, Raja B, Manivannan J, Silambarasan T, Prahalathan P, Kumar S, Mishra SK.  |  The antioxidative properties of vanillic acid esters were systematically evaluated by multiple assays to compare with the well-known antioxidants, vanillic acid and Trolox. Methods: 2014 Sep 12;19(9):14496-527. doi: 10.3390/molecules190914496. J Ethnopharmacol. During cultivation, phenolic compounds such as syringic acid and vanillic acid are produced by lignin-degrading peroxidase secreted from L. edodes mycelia. Epub 2014 Jul 10.

2020 Mar 9;21(5):1868. doi: 10.3390/ijms21051868. Antioxidants (Basel).

Br J Nutr. Diets high in fat are strongly associated with the development of obesity and can induce insulin resistance in humans and animals. Based on the results of the present study, we propose the addition of antioxidant capacity to the multifunctionality of vanillin. It is known that lignin-derived phenolic compounds (vanillin, ferulic acid, benzoate, 4-hydroxybenzoate, vanillate, and phenol) are the main growth inhibitors in lignocellulosic hydrolyzates for microbial fermentation. The dimerization contributed to the high reaction stoichiometry against ABTS(+) and AAPH-derived radicals to result in the strong effect of vanillin.

Part 2. Background:

2011;75(12):2346-50. doi: 10.1271/bbb.110524. Chuang HW, Wei IH, Lin FY, Li CT, Chen KT, Tsai MH, Huang CC. Int J Mol Sci.

2020 Sep 1;98(9):skaa259. Get the latest research from NIH: NLM Vanillin showed stronger activity than did ascorbic acid and Trolox in the ABTS(+)-scavenging assay but showed no activity in the DPPH radical- and galvinoxyl radical-scavenging assays.

Mol Cell Endocrinol.


Moniruzzaman M, Khalil MI, Sulaiman SA, Gan SH.

Protective role of Scoparia dulcis plant extract on brain antioxidant status and lipidperoxidation in STZ diabetic male Wistar rats. Clipboard, Search History, and several other advanced features are temporarily unavailable. Cantele C, Rojo-Poveda O, Bertolino M, Ghirardello D, Cardenia V, Barbosa-Pereira L, Zeppa G. Foods.

Formulation of More Efficacious Curcumin Delivery Systems Using Colloid Science: Enhanced Solubility, Stability, and Bioavailability. 2020 Aug;17(4):432-439. doi: 10.4274/tjps.galenos.2019.92678. Rodríguez-Correa E, González-Pérez I, Clavel-Pérez PI, Contreras-Vargas Y, Carvajal K. Nutr Diabetes. The antioxidant activities were significantly increased and the levels of lipid peroxidation markers were significantly decreased in diabetic hypertensive rats treated with vanillic acid.

2019 Dec 2;24(23):4405. doi: 10.3390/molecules24234405. Antioxidant capacity and radical scavenging effect of polyphenol rich Mallotus philippenensis fruit extract on human erythrocytes: an in vitro study. 2020 Feb 13;5(7):3709-3716. doi: 10.1021/acsomega.9b04271. Biosci Biotechnol Biochem. Afr J Tradit Complement Altern Med. 2011. Shanmugasundaram KR, Ramanujam S, Shanmugasundaram ER. Epub 2014 Jul 10. Turk J Pharm Sci. Background: Vanillin, a compound widely used in foods, beverages, cosmetics and drugs, has been reported to exhibit multifunctional effects such as antimutagenic, antiangiogenetic, anti-colitis, anti-sickling, and antianalgesic effects. Methods Mol Biol. Antioxidative properties of ascorbigen in using multiple antioxidant assays. Epub 2012 Jun 18. We first performed assays with the model radicals, DPPH, galvinoxyl and ABTS cation (ABTS(•+)) types. 2019 Jul 9;24(13):2512. doi: 10.3390/molecules24132512.

Tong Y, Liu S, Gong R, Zhong L, Duan X, Zhu Y. Oxid Med Cell Longev. 2014;78(10):1723-30. doi: 10.1080/09168451.2014.932668. NLM Zhang J, Zhou R, Xiang C, Jia Q, Wu H, Yang H. Oxid Med Cell Longev. Biosci Biotechnol Biochem. 2014;2014:279451. doi: 10.1155/2014/279451.  |  Biosci Biotechnol Biochem.

NLM General significance:



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Epub 2015 Sep 8. In the ABTS(+)-scavenging assay, ORAC assay and OxHLIA, vanillin reacted with radicals via a self-dimerization mechanism.

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Get the latest research from NIH: 2012 Sep;165(6):638-47. doi: 10.1016/j.chemphyslip.2012.05.003.  |  Antioxidant activity and mechanisms of action of natural compounds isolated from lichens: a systematic review. Many herbs and foods contain vanillic acid, including arnica, bilberry, centaury, cinnamon, chamomile, chickweed, ginseng, mistletoe, red sandalwood, Shiitake mushrooms, and whole wheat.